贾子善,赵大为,槐雅萍,何春年,李聪元.运动训练对局灶性脑梗死大鼠梗死灶周围皮层NCAM mRNA表达的影响[J].中国康复医学杂志,2005,20(7):502~503 |
运动训练对局灶性脑梗死大鼠梗死灶周围皮层NCAM mRNA表达的影响 点此下载全文 |
贾子善 赵大为 槐雅萍 何春年 李聪元 |
河北省人民医院康复中心,河北省人民医院神经内科,河北省人民医院康复中心,石家庄市河北省人民医院病理科,河北省人民医院康复中心 050051,050051,050051 |
基金项目:河北省科技攻关计划项目(No.012761233) |
DOI: |
摘要点击次数: 2335 |
全文下载次数: 125 |
摘要: |
目的:探讨运动训练对脑梗死大鼠梗死灶周围皮层NCAMmRNA表达的影响。方法:用Wistar大鼠制作大脑中动脉阻塞(MCAO)模型。48h后随机分为3组:运动训练组、手术对照组、假手术对照组。每组均单独饲养于小鼠笼中,运动组每天被动跑笼40min。在MCAO后7、14、21、28天用原位杂交的方法检测梗死灶周围皮层NCAMmRNA的表达。结果:梗死灶周围皮层NCAMmRNA表达明显增加(P<0.01),运动训练组梗死灶周围皮层NCAMmRNA表达明显高于非训练组(P<0.05)。结论:脑缺血梗死可明显诱发NCAMmRNA的表达,运动训练可增加其表达。 |
关键词:脑梗死,运动,大鼠,神经细胞黏附分子 |
Effect of exercise training on expression of NCAM mRNA after cerebral infarction in rats Download Fulltext |
|
|
Fund Project: |
Abstract: |
Objective:To study the effects of exercise training on expression of NCAM mRNA after cerebral infarction in rats.Method:The right middle cerebral artery was occluded with electric coagulation in Wistar rats. The rats were feed in small cages and were randomly divided into three groups 48 hours later. Training group which was given wheel-running exercise everyday(n=20). Control group(n=20) and sham-operated group(n=10).The expression of NCAM mRNA in cortex of the three groups was detected at 1w,2w,3w and 4w after the MCAO.Result: In the cortex around the infarcted focus,the expressions of NCAM mRNA elevated much significantly after cerebral infarction(P<0.01). The expression of NCAM mRNA in training group was higher than that in control group(P<0.05).Conclusion:The cerebral infarction induces the expression of NCAM mRNA. The training exercise can enhance its expression. |
Keywords:cerebral infarction,exercise training,rats,NCAM mRNA |
|
查看全文 查看/发表评论 |
|
|
|
|
|