低频脉冲电磁场治疗骨质疏松症的Meta分析

关键词：低频脉冲电磁场 骨质疏松症 系统评价／Meta分析

Keywords:pulsed electromagnetic fields  osteoporosis  systematic review/meta analysis

摘要：

      目的：评价低频脉冲电磁场（PEMFs）治疗骨质疏松症的疗效和安全性。方法：计算机检索中国数字医院图书馆全文数据库1994年1月-2004年12月、中国生物医学文献光盘数据库1995年1月-2004年12月。由两名评价者独立对纳入文献进行质量评价，并提取资料，如有分歧，通过讨论解决。采用RevMan4．2．5进行Meta分析：结果6篇文献、共204例患者符合纳入标准，其中随机对照试验2篇。结果：骨质疏松症患者经低频脉冲电磁场治疗后与治疗前相比较，加权均数差（WMD）=0．04，95％CI为[0．02，0．06]，整体效果检验Z=3．46，P=0．0005，疗效差异有极显著性意义，在森林图中，WMD的95％CI横线落在无效竖线右侧，故认为低频脉冲电磁场治疗骨质疏松症有效。低频脉冲电磁场与对照药物的疗效差异尚无显著性意义：结论：从现有的临床证据来看，低频脉冲电磁场治疗骨质疏松症有效，安全性较高，但还非常需要高质量的随机对照试验来进一步验证。

Abstract:

      Objective:To evaluate the efficacy and safety of pulsed electromagnetic fields(PEMFs) for osteoporosis. Method:www.chkd.cnki.net(1994.1-2004.12) and CBMdisk(1995.1-2004.12) were electronically searched. The quality of literature was reviewed, and the data were extracted by two reviewers independently. Meta analysis was conducted used RevMan 4.2.5 software. Result:Six controlled trial involving 204 patients were included, of the 6 controlled trial, two were of RCT. Meta analysis indicated that the WMD 0.04, 95%CI 0.02 to 0.06, test for overall effect Z 3.46, P=0.0005. After the treatment versus before treatment the divergence of curative effect had the high statistical significance. In forest plot, the 95%CI horizontal line of WMD dropped to being living the invalid upright string right side. Conclusion:Actual clinical evidence indicates that the pulsed electromagnetic fields is efficacy and safety for osteoporosis. More randomized controlled trials of high quality are needed for stronger evidence.