运动训练对血管性痴呆大鼠认知障碍及长时程增强的影响

关键词：血管性痴呆 运动训练 水迷宫 长时程增强

Keywords:vascular dementia  exercise training  water maze  long-term potentiation

摘要：

      目的：探讨运动训练对大鼠空间学习、记忆能力和长时程增强（LTP）的影响。方法：选用Wistar雄性大鼠随机分成对照组5只，血管性痴呆组10只，血管性痴呆＋运动训练组10只。用电生理学方法检测在体海马CAI区LTP。用Morris水迷宫评价大鼠学习记忆能力。结果：血管性痴呆组大鼠水迷宫逃避潜伏期明显延长．血管性痴呆＋运动训练组大鼠较血管性痴呆组大鼠水迷宫隐匿平台逃避潜伏期缩短，但仍长于对照组（P〈0．05）。血管性痴呆组大鼠LTP诱导明显受到抑制，血管性痴呆＋运动训练组大鼠较血管性痴呆组大鼠LTP诱导明显改善．但仍比对照组差（P〈0．05）。结论：血管性痴呆大鼠学习记忆能力降低，LTP诱导障碍，运动训练可提高大鼠空间学习、记忆能力，增强LTP的形成．

Abstract:

      Objective:To investigate the effects of exercise training on the ability of spatial learning,memory and long-term potentiation(LTP) in hippocampus CA1 region in rats.Method:Twenty-five Wistar male rats were divided into control group(n=5),vascular dementia group(n=10) and vascular dementia with exercise training group(n=10).Electrophysiological technique was used to observe the effects on LTP of hippocampal CA1 region.Morris water-maze test was performed to study the ability of spatial learning and memory in each group of rats.Result:The escape latencies in vascular dementia group were longer than those control group,and after exercise training it became shorter,but were still longer than the control group(P<0.05).The change rates of population spike(PS) latency in exercise training group were statistically higher than those in vascular dementia group(P<0.05).Conclusion:Exercise training can significantly elevate the induction of LTP and the ability spatial of learning and memory.