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宋为群,李永忠,杜博琪,徐倩,杜巨豹,潘钰,吴东宇,杨远滨,周景升,罗跃嘉,王茂斌.低频重复经颅磁刺激治疗视觉空间忽略的临床研究[J].中国康复医学杂志,2007,22(6):483~
低频重复经颅磁刺激治疗视觉空间忽略的临床研究    点此下载全文
宋为群  李永忠  杜博琪  徐倩  杜巨豹  潘钰  吴东宇  杨远滨  周景升  罗跃嘉  王茂斌
[1]首都医科大学宣武医院康复科,北京100053 [2]教育部神经变性病重点实验室,北京100053 [3]首都医科大学宣武医院放射科,北京100053 [4]北京师范大学认知神经科学与学习国家重点实验室,北京100053
基金项目:国家自然科学基金(30540058,30325026,30370489);中国科学院重要方向项目(KSCX2-SW-221);北京市自然科学基金(7052030):北京市委组织部优秀人才基金;北京市科技计划项目(Z0005187040191-1)资助
DOI:
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摘要:
      目的:采用低频重复经颅磁刺激(rTMS)对视觉空间忽略的患者进行治疗,通过行为学方法观察其治疗前后忽略的变化并探讨其脑机制。方法:14例脑血管意外后伴视觉空间忽略两周后无自然恢复的患者,分为治疗组和对照组各7例,治疗组采用rTMS进行治疗,刺激强度为运动阈值的90%,频率0.5Hz,刺激位点位于患者健侧大脑的顶叶后部(EEG10-20标准的P3点)。每次治疗15min,每天2次,连续治疗2周。并连续观察治疗两周后忽略的变化情况。结果:经过rTMS对左侧大脑的顶叶后部进行连续刺激两周后,患者的忽略明显改善。其中线段划消及直线二等分测试均表现为治疗前后有明显的差异。结论:使用rTMS后,患者的视觉空间忽略明显改善。经颅磁刺激治疗作为一种无创性的治疗方法,对视觉空间忽略有效。本结果支持注意网络的半球竞争理论。
关键词:视觉空间忽略 低频重复经颅磁刺激 脑卒中 康复
Effects of low frequency repetitive transcranial magnetic stimulation on patients with visual spatial neglect    Download Fulltext
SONG Weiqun  LI Yongzhong  DU Boqi  et al
Dept. of Rehabilitation, Xuanwu Hospital,Capital Medical University, Beijing,100053
Fund Project:
Abstract:
      Objective: To investigate the effects of low frequency repetitive transcranial magnetic stimulation (rTMS) on patients with visual spatial neglect and to explore the potential mechanisms of the visual spatial neglect. Method: Fourteen patients with visual spatial neglect whose symptoms were not eliminated naturally had been involved in this study. They were divided into two groups as control group and treatment group. The treatment group was treated with low frequency repetitive rTMS for 2 weeks, two times a day and 15 minutes each, the frequency of the stimulation is 0.5Hz. The stimulant position is the left posterior parietal cortex (ie. the position P3 according to 10-20 EEG coordinate system). All the patients performed a battery of task including line bisection, line cancellation 2 weeks before,at the beginning, the end and 2 weeks after the treatment. Result: By using the low frequency rTMS, we found the treatment group patients, performance improved significantly. Conclusion: There is a significant improvement in visual spatial performance by using low frequency rTMS. The outcome suggested that using low frequency rTMS, as a non-invasive method, might be an effective rehabilitative treatment for patients with visual spatial neglect. The results of our studies support a theory of inter-hemispheric competition in the attentional network.
Keywords:visual spatial neglect  transcranial magnetic stimulation  rehabilitation
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