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高俊淑,李阔,$2,贾子善.探索学习对局灶性脑梗死大鼠梗死灶周围皮质BDNF表达的影响[J].中国康复医学杂志,2007,22(7):584~
探索学习对局灶性脑梗死大鼠梗死灶周围皮质BDNF表达的影响    点此下载全文
高俊淑  李阔  $2  贾子善
[1]河北省人民医院神经二科,石家庄050051 [2]河北省人民医院康复中心,石家庄050051
基金项目:河北省卫生厅资助课题(03025)
DOI:
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摘要:
      目的:观察探索学习对局灶性脑梗死大鼠脑源性神经营养因子(BDNF)表达的影响。方法:SD大鼠75只,采用电凝法造成右侧大脑中动脉阻断(MCAO)模型后,随机分为独居组(n=20)、社交组(n=30)、探索学习组(n=20)、似手术对照组(n=5)。于不同时点分批处死大鼠,用免疫组化染色观察梗死灶周围皮质BDNF阳性细胞数。结果:梗死灶周围皮质BDNF阳性神经元明显增加。探索学习组BDNF阳性神经元数量在各个时间点均明显高于独居组和社交组(P〈0.01),独居组在7天、14天、28天时BDNF阳性神经元数量低于社交组(P〈0.01或P〈0.05)。结论:探索学习及社会交往均能促进梗死灶周围皮质BDNF表达。
关键词:探索学习 社会交往 脑梗死 大鼠 脑源性神经营养因子
The effect of learning on BDNF expression in rats after unilateral local cerebral infarction    Download Fulltext
GAO Junshu  LI Kuo  LI Na  et al
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Abstract:
      Objective:To study the effect of learning on BDNF expression in rats after unilateral local cerebral infarction.Method:After making the model of MCAO by electric coagulation successfully,75 male rats were randomly divided into individual living group(n=20),social communication group(n=30),learning group(n=20) and sham operated group(n=5).The rats were randomly sacrificed at different time points.The expression of BDNF in peri-ischemic cortex was examined by immunohistochemistry staining.Result:The number of BDNF labeled cells in peri-ischemia cortex in learning group was higher than that in individual living group and social communication group(P<0.01),it was also higher in social communication group than that in individual living group at the 7th,14th,28th after MCAO(P<0.01 or P<0.05).Conclusion:Learning and social communication could enhance BDNF expression in rats after unilateral local cerebral infarction.
Keywords:learning  social communication  cerebral infarction  rat  brain-derived neurotrophic factor
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