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葛红卫,何延政,梅 燕,刘 勇,曾 宏,施 森,文雪刚.运动训练对大鼠缺血下肢血管新生的影响[J].中国康复医学杂志,2008,23(5):413~415
运动训练对大鼠缺血下肢血管新生的影响    点此下载全文
葛红卫  何延政  梅 燕  刘 勇  曾 宏  施 森  文雪刚
苏州大学附属第三医院血管外科,213003
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摘要:
      目的:观察下肢缺血及运动训练对大鼠缺血下肢微血管生成的影响。方法:SD大鼠30只随机分为A、B、C 3组各10只,A、B组建立大鼠下肢缺血模型,C组仅作皮肤切开缝合。建模1周后A组大鼠跑步训练(30min/d)。B、C组日常活动,运动训练4周后处死大鼠,取大腿内收肌组织块免疫组化检测微血管密度(MVD)、血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)表达,比较3组差异。结果:肌组织MVD、VEGF、bFGF免疫组化均显示:A组高于B组(P<0.01),B组高于C组(P<0.01);A、B、C组间差异均存在显著性。结论:下肢缺血刺激可以促进血管新生、成血管因子表达增加,运动训练可以增强该效应。
关键词:缺血  运动训练  血管新生
Effects of hindlimb ischemia and exercises training on microangium in rats with ischemic limbs    Download Fulltext
The Third Hospital of Suzhou University,213003
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Abstract:
      Objective:To observe the effects of hindlimb ischemia and exercises training on microangium in rats with ischemic limbs.Method:Thirty health male Sprague-Dawley rats were divided into experiment group(A),control group(B) and pseudosurgery group(C) randomly. Hindlimb ischemia was established in rats(A and B) by surgical excision of right femoral arteries.Rats in group A were trained to run 30min once a day at the standard for 4 weeks,then all the rats were sacrificed to obtain the adductor of the ischemic upper leg and fix. MVD、VEGF、bFGF in tissues were measured by immunohistochemistry to compare the difference among 3 groups. Result:MVD、VEGF、bFGF in tissues measured by immuno-histochemistry techniques displayed as:group A>group B(P<0.01);group B > group C(P<0.01),significant differences were among group A、B and C.Conclusion:Lower limb ischemia can increase the angiogenesis and exercises training can enhance this effect.
Keywords:ischemia  exercises training  angiogenesis
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