高压氧对脑外伤患者精神障碍的影响

关键词：高压氧；脑外伤；长谷川痴呆量表  记忆商数  汉密尔顿抑郁量表

Keywords:hyperbaric oxygen  traumatic brain injury  memory quotient  Hastgawa dementia scale  Hamilton depression rating scale

摘要：

      目的：评价高压氧（HBO）治疗脑外伤（TBI）的效果，探讨HBO治疗TBI精神障碍的临床价值。方法：将60例脑外伤患者分为高压氧综合治疗组和对照组，两组均以格拉斯哥结局量表（GOS）判断疗效，并测定两组患者治疗前后MQ、HDS、HAMD得分，进行比较判定。结果：高压氧组治疗后GOS评分为4.37±0.96，对照组为3.77±0.97，高压氧组明显优于对照组，差异具有显著性（P<0.05）。两组患者治疗前MQ、HDS得分明显减少，治疗后均较治疗前增加，差异具有显著性（P<0.01），高压氧组MQ、HDS得分明显高于对照组，差异具有显著性（P<0.05）。两组患者治疗前HAMD得分明显提高，治疗后均较治疗前降低，HBO组HAMD得分明显低于对照组，差异具有显著性(P<0.05)。结论：HBO能进一步提高TBI患者MQ、HDS得分，降低TBI患者HAMD得分，促进患者脑功能的恢复，增加治疗疗效，改善TBI患者精神心理状态。

Abstract:

      Objective: To evaluate the effects of hyperbaric oxygen(HBO) therapy on mental disorders of patients with traumatic brain injury(TBI). Method: Sixty patients with TBI were divided into two groups randomly: HBO (combined treatment) group and control group. The curative effects of HBO group and control group were measured after 3 courses of treatment by means of Glasgow outcome scale(GOS). The scores of MQ、HDS and HAMD in both groups were measured before and after 3 courses of treatment. Result: The GOS scores of HBO group was 4.37±0.96, that of control group was 3.77±0.97, HBO group had a preferable effect(P<0.05). After 3 courses of treatment, the scores of MQ, HDS elevated in both groups(P<0.01), and in HBO group that was obvious higher than that in control group(P<0.05); while the scores of HAMD redueed in both groups, and there was significant difference between two groups(P<0.05), that in HBO group was obvious lower than that in control group. Conclusion: ①The therapeutic effect of HBO combined with conventional neurosurgery therapy is much better than that of conventional neurosurgery therapy only. ②HBO can elevate the scores of MQ、HDS and reduce the scores of HAMD in patients with TBI, accordingly HBO can improve mental state in patients with TBI.