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张 波,王亚非,刘雪丽,安雅莉,巩秋红,卜 石,帅 英,张金苹,李光伟.TNF-α对短期胰岛素强化治疗诱导短病程2型糖尿病长期缓解的预测作用[J].中国康复医学杂志,2009,24(6):547~549
TNF-α对短期胰岛素强化治疗诱导短病程2型糖尿病长期缓解的预测作用    点此下载全文
张 波  王亚非  刘雪丽  安雅莉  巩秋红  卜 石  帅 英  张金苹  李光伟
卫生部中日友好医院内分泌代谢病中心,北京,100029
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摘要:
      目的:研究短病程2型糖尿病患者经短期胰岛素强化治疗获长期缓解的预测因素。方法:入选36例病程不超过半年的初诊2型糖尿病患者,给以2周的胰岛素强化治疗。强化治疗前及结束24h后分别进行标准餐试验和静脉葡萄糖耐量试验。治疗后不用任何降糖药物血糖能良好控制1年视为长期缓解。 结果:长期缓解率为80.6%(29/36)。缓解组基线TNF-α水平(1.86±1.90ng/L,n=29)强化治疗后降至1.39±2.18ng/L,P<0.001。未缓解组(n=7)TNF-α水平无显著降低。△TNF-α(基线-治疗后)水
关键词:2型糖尿病  肿瘤坏死因子α  胰岛素强化治疗  长期缓解
Predictors of long-term remission induced by short-term intensive insulin treatment in type 2 diabetic patients of short course    Download Fulltext
Department of Endocrinology, China-Japan Friendship Hospital, Beijing, 100029
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Abstract:
      Objective: To investigate the predictors for the long-term remission of type 2 diabetes of short course induced by means of short-term intensive insulin treatment. Method: 36 cases of diabetic patients with high level of hyperglycemia and duration no more than 0.5 year received the two-week long intensive insulin treatment. Remission meant that the diabetic patients should maintain the desired glycaemic control without any hypoglycaemic agents within one year. Result: The remission rate was up to 80.6% (29/36). The TNF-α at baseline in remission group was 1.86±1.90ng/L(n=29), and the level after intensive treatment decreased to 1.39±2.18ng/L,P<0.001. No significant decrease was observed in non-remission group(n=7). △TNF-α level (at baseline minus that after treatment) was positively correlated with the long-term remission event in Spearman analysis, r=0.428, P=0.010. Conclusion: The long-term remission can be induced in most newly-diagnosed type 2 diabetic patients. △TNF-α is the most important predictor for the long-term remission event.
Keywords:type 2 diabetes  tumor necrosis factor  intensive insulin treatment  long-term remission
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