间歇性低氧及游泳运动对大鼠右心室线粒体超微结构的影响

关键词：间歇性低氧  运动  线粒体  大鼠

Keywords:intermittent hypoxia  exercise  mitochondria  rat

摘要：

      摘要 目的：观察间歇性低氧及游泳运动对大鼠右心室线粒体超微结构的影响，为高原医学的研究提供实验资料。 方法：Wistar大鼠随机分为常氧对照组、低氧对照组和低氧运动组。用MPA-心功能分析系统记录血压和心率。用透射电镜观察右心室线粒体超微结构。 结果：低氧对照组：大鼠肌原纤维间大量增生线粒体挤压变形，线粒体嵴和基质明显增多，线粒体间见大量空泡。线粒体排列无序，线粒体凝集变形。低氧运动组：肌膜下线粒体较多，线粒体排列有序。高倍镜下可见线粒体基质增多。结论：低氧对大鼠右心室线粒体的超微结构有一定的损伤，低氧及游泳运动对大鼠右心室线粒体超微结构有明显改善。

Abstract:

      Abstract Objective: To observe the mitochondria ultrastructure of right ventricle during intermittent hypoxia and swimming exercise in rats to offer experimental data in plateau iatrical research. Method: Wistar rats were randomly divided into the normoxia control group, the hypoxia control group and the hypoxia training group. Blood pressure and heart rate were recorded by MPA-heart function analytical system. Mitochondria ultrastructure of right ventricle was observed by transmission electron microscope. Result: The hypoxia control group: Mitochondria hyperplasia, extruded deformation, mitochondrial crista and matrix increasing obviously and a great quantity vacuoles among mitochondria were found. Disarrangement and agglutinative deformation of mitochondria were also observed. The hypoxia training group: Mitochondria increasing under sarcolemma and arranging regularly were found. Mitochondrial matrix increasing could be observed under high power lens. Conclusion: The mitochondria ultrastructure of right ventricle was damaged during hypoxia, and the mitochondria ultrastructure of right ventricle improved significantly during intermittent hypoxia and swimming exercise.