大鼠部分重量支撑平板训练新模型在不完全性脊髓损伤运动功能改善中的应用

关键词：脊髓损伤  部分重量支撑平板训练  运动功能

Keywords:spinal cord injury  body weight support treadmill training  locomotor function

摘要：

      摘要 目的：探讨部分重量支撑平板训练（BWSTT）新模型对不完全性SCI大鼠功能改善的效果。 方法：成年健康SD大鼠40只，随机分成对照组、实验组，采用改良Allen撞击法制作脊髓不完全损伤模型。实验组大鼠采用自制装置进行BWSTT。在不同时间点采用斜板试验、改良Tarlov评分、BBB评分进行运动功能评定。 结果：实验组大鼠运动训练2—4周组，斜板实验、改良Tarlov评分、BBB评分均较对照组显著提高（P<0.05），训练3周和４周组较训练1周和2周组显著提高（P<0.05）。 结论：BWSTT新模型能有效改善不完全性脊髓损伤大鼠运动功能，并与运动训练时程相关。

Abstract:

      Abstract Objective：To study influences of new model of body weight support treadmill training(BWSTT) on the improvement of locomotor function in incomplete after spinal cord injury(SCI) rats. Method：Forty healthy adult SD rats were randomly divided into control group and training group. Incomplete SCI rat model was made by extradural compression using modified Allen′s stall with damage energy of 40 gcm force. These rats were loosely restrained on treadmill. Locomotor function was evaluated by inclined plane tests, modified Tarlov scores, Basso-Beattie-Bresnahan(BBB) scales. Result：Rats′ locomotor function improved significantly after new model of BWSTT in different durations compared with control group（P<0.05）. The effects of 3-week and 4-week training were better than that of 1-week and 2-week training（P<0.05）. Conclusion：New model of BWSTT might improve the locomotor function of incomplete SCI rats, and the effect was correlated closely with the duration of exercise training.