有氧运动对冠状动脉慢血流患者的疗效及血小板功能的影响

关键词：冠状动脉慢血流现象  有氧运动  血小板膜糖蛋白受体

Keywords:coronary slow flow phenomenon  aerobic exercise  platelet membrane glycoprotein receptor

摘要：

      摘要 目的：探讨有氧运动对冠状动脉慢血流患者的疗效及血小板功能的影响。 方法：冠状动脉造影诊断为冠状动脉慢血流的患者43例，观察在常规治疗的基础上，规律有氧运动前后的临床症状，血小板膜CD62P、CD61的阳性百分率（%）及血小板聚集率的变化。 结果：在常规治疗的基础上行运动疗法3个月，胸痛症状明显减轻； 运动后与运动前相比，血小板膜CD62P阳性百分率(%)分别为23.6±3.5及30.3±3.4 (P<0.05) 、CD61阳性百分率(%)分别为22.1±2.8及28.3±3.5 (P<0.05)，血小板聚集率(%)分别为61.3±4.3及71.5±5.7 (P<0.05)。 结论：规律运动可以改善冠状动脉慢血流患者的症状，降低患者血小板表面活化受体分子的活性及血小板聚集。

Abstract:

      Abstract Objective： To explore effects of aerobic exercise on symptoms and platelet function in patients with coronary slow flow phenomenon. Method:Forty-three patients with coronary slow flow phenomenon were selected. Aerobic exercise with moderate intensity was 30 min per session,5 sessions per week for 3 months. Clinical symptoms were observed, and the changes of positive percentages of platelet membrane glycoprotein CD62P, CD61(Ⅲa) determined by flow cytometric analysis and platelet aggregating ratio were measured before and after regular aerobic exercise. Result: Based on conventional treatment after three months of aerobic exercise, chest pain of patients with coronary slow flow reduced obviously, and positive percentages of platelet membrane glycoproten CD62P(23.6±3.5 vs 30.3±3.4, P＜0.05),CD61(Ⅲa)(22.1±2.8 vs 28.3±3.5,P＜0.05) and platelet aggregating ratio（PAR）(61.3±4.3 vs 71.5±5.7,P＜0.05) decreased significantly compared with the level before aerobic exercise. Conclusion: Regular aerobic exercise could improve symptoms and decrease the positive percentage of platelet membrane glycoprotein and platelet aggregating ratio in patients with coronary slow flow phenomenon.