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宋成宪,范建中,吴红瑛,魏 轶,甄健荣.脉冲磁场对脑损伤患者脑脊液和血清中胰岛素样生长因子-1含量的影响[J].中国康复医学杂志,2010,25(12):1152~1156
脉冲磁场对脑损伤患者脑脊液和血清中胰岛素样生长因子-1含量的影响    点此下载全文
宋成宪  范建中  吴红瑛  魏 轶  甄健荣
南方医科大学南方医院康复医学科,广州,510515
基金项目:广东省医学科研基金课题(A2007384)
DOI:
摘要点击次数: 2052
全文下载次数: 1948
摘要:
      摘要 目的:研究脉冲磁场对脑损伤患者脑脊液和血清中胰岛素样生长因子-1(IGF-1)变化的影响。 方法:将65例脑损伤恢复期患者随机分为试验组(35例)和对照组(30例)。试验组在常规治疗的基础上,加用双颞部脉冲磁场治疗(20—40mT,50Hz,20min/次,1次/d,共14d);对照组除未给予脉冲磁场治疗外,余治疗均与试验组基本相同。所有患者均在入组后第1天和第14天清晨空腹抽取静脉血4ml,并在抽血当天行腰椎穿刺检查,留取脑脊液4ml。IGF-1的测定采用放射免疫法,葡萄糖测定采用葡萄糖氧化酶法。 结果:试验组和对照组脑脊液和血清中IGF-1含量、葡萄糖水平治疗前差异无显著性意义(P>0.05)。经脉冲磁场治疗14d后,试验组脑脊液中IGF-1含量高于治疗前和对照组(P<0.05);试验组和对照组血清中IGF-1含量治疗后较前有所增加,但差异无显著性意义(P>0.05),治疗后两组之间差异亦无显著性意义(P>0.05);对照组脑脊液中IGF-1含量治疗前后无明显变化(P>0.05)。试验组和对照组脑脊液和血清中葡萄糖水平治疗前后均无明显变化(P>0.05)。 结论:脉冲磁场可以使脑损伤恢复期患者脑脊液中IGF-1浓度升高,对血清中IGF-1含量无影响,脑脊液及血清中IGF-1的变化不会造成葡萄糖水平的波动,说明脉冲磁场在脑损伤恢复期患者的治疗中有一定的应用价值。
关键词:脉冲磁场  胰岛素样生长因子-1  脑损伤
Effects of pulsed magnetic field on insulin-like growth factor-1 in cerebrospinal fluid and serum of patients with brain injury    Download Fulltext
Department of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515
Fund Project:
Abstract:
      Abstract Objective:To study the effects of pulsed magnetic field on insulin-like growth factor-1(IGF-1)in cerebrospinal fluid (CSF) and serum of patients with brain injury. Method: Sixty-five patients with brain injury were divided into two groups randomly: the control group with 30 patients and the magnetic therapy group with 35 patients. Both groups received conventional therapy ; meanwhile, magnetic group received pulsed magnetic field treatment(20-40mT , 50Hz, 20min per time, once a day,14d) on bilateral temples. On the 1st d and 14th d, 4ml fasting blood were drawn from all the patients on the morning. And 4ml CSF were also drawn from all the cases on the same day. Glucose was measured by glucose oxidase method; IGF-1 was measured by radioimmunoassay (RIA) . Result:Before treatment concentrations of IGF-1 and glucose in CSF and serum had no difference between two groups(P>0.05). After treatment of 14d, concentrations of IGF-1 in CSF of magnetic group were significantly higher than those before treatment and the controls (P<0.05). IGF-1 in serum of two groups increased compared with those before treatment (P>0.05), but there was no significant difference between two groups also (P>0.05). IGF-1 in CSF of control group had no difference than before(P>0.05). The concentration of glucose in CSF and serum had no significant change than before treatment(P>0.05) . Conclusion: Pulsed magnetic field might improve the concentration of IGF-1 in CSF of the patients with brain injury. Meanwhile, there was no effect on IGF-1 in serum. And the changed concentrations of IGF-1 had no effect on glucose. Pulsed magnetic field might have certain effects on patients with brain injury.
Keywords:pulsed magnetic field  insulin-like growth factor-1  brain injury
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