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周 蔚,陈立军,张 敏,靳秋月,谢 红,史 娜.跑台运动训练对大鼠脑组织抗氧化能力的影响[J].中国康复医学杂志,2011,26(5):447~450
跑台运动训练对大鼠脑组织抗氧化能力的影响    点此下载全文
周 蔚  陈立军  张 敏  靳秋月  谢 红  史 娜
武警医学院生物化学教研室,天津,300162
基金项目:军队科研项目(WKH2009Z02)
DOI:
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摘要:
      摘要 目的:建立大鼠跑台运动模型,观察不同训练负荷对大鼠脑组织总抗氧化能力(T-AOC),过氧化氢酶(CAT),羟自由基(OH·)的影响。 方法:建立有氧、无氧、有氧和无氧交替运动大鼠跑台运动训练模型,有氧运动时采用递增负荷训练,无氧运动时采用高速间歇训练,并设立正常对照组。各组大鼠训练结束后用机器匀浆法提取大鼠脑组织匀浆介质,紫外分光光度计检测大鼠脑组织T-AOC,CAT活性和OH·抑制能力。 结果:有氧组大鼠OH·抑制能力要低于其他各组(P<0.05),但训练6周后,和其他组相比差异无显著性意义;交替组大鼠脑组织CAT活性要高于其他三组(P<0.05),而无氧组偏低(P<0.01);有氧运动组大鼠脑组织T-AOC要高于正常对照组(P<0.01)。 结论:有氧运动的氧化损伤要强于其他各组,但是随着训练时间的延长,其抗氧化能力也随之加强。长期坚持适度的有氧运动将有利于机体提升抗氧化损伤的能力。
关键词:跑台运动  脑组织  总抗氧化能力  过氧化氢酶  羟自由基
Effect of treadmill exercises on antioxidant capacity in the brain of rats    Download Fulltext
Department of Biochemistry, Armed Police Medical College, Tianjin, 300162
Fund Project:
Abstract:
      Abstract Objective: To establish a rat treadmill exercises model and to investigate the activity changes of total antioxidant capacity (T-AOC), catalase (CAT) and hydroxyl free radical(OH·) in rat brain after treadmill exercises training of different intensity. Method: Eighty male SD rats were randomly divided into four groups: normal control group, aerobic exercises group (incremental load exercise), anaerobic exercises group (high-speed intermittent training) and alterntive-training group aerobic and anaerobic alternative training. The activity of T-AOC, CAT and the inhibition ability of OH· were measured after every training period. Result: The inhibition ability of OH· of rat brain in aerobic exercise group was lower than that in the other groups (P<0.05). However, after six-week training, there was no significant difference between four groups. Activity of CAT rat brain in alternative-training group was higher than that in the other three groups (P<0.05), and it was low in anaerobic group (P<0.01). The T-AOC of rat brain in aerobic exercise group was higher compared with normal control group (P<0.01). Conclusion: Oxidative damages of aerobic exercise were heavier than the other groups. But with the extension of training period, the antioxidant capacity increased. It suggested that after moderate aerobic exercises for a long term organism's antioxidant activity would be enhanced.
Keywords:treadmill exercise  brain tissue  total antioxidant capacity  catalase  hydroxyl free radical
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