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雒生杰,李建军,周红俊.载脂蛋白A1水平在不同脊髓损伤患者中的差异性研究[J].中国康复医学杂志,2011,26(10):935~938
载脂蛋白A1水平在不同脊髓损伤患者中的差异性研究    点此下载全文
雒生杰  李建军  周红俊
中国康复研究中心北京博爱医院,北京,100068
基金项目:
DOI:
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摘要:
      摘要 目的:通过对不同脊髓损伤患者血清载脂蛋白A1(ApoA-I)水平回顾性资料的流行病学调查,进行差异比较和相关因素分析,探讨造成这一心血管保护因子差异形成的可能机制和临床意义。 方法:对中国康复研究中心2004年1月—2010年12月因脊髓损伤入院进行康复治疗的患者进行入院后ApoA-I水平回顾性调查。 结果:女性脊髓损伤患者ApoA-I水平高于男性患者,截瘫患者ApoA-I水平高于四肢瘫患者,男性患者ApoA-I水平还受年龄和病程影响,女性患者ApoA-I水平与年龄和病程不相关。 结论:ApoA-I水平在不同脊髓损伤类型患者间存在差异,男女不同性别之间也存在差异,雌激素保护作用和运动能力不同可能是造成差异的主要原因。
关键词:载脂蛋白A1  脊髓损伤  性别  运动
Investigation on apolipoprotein A-I levels in spinal cord injury patients    Download Fulltext
Beijing Charity Hospital of CRRC, Beijing, 100068
Fund Project:
Abstract:
      Abstract Objective: To epidemiologically investigate the retrospective-data-based serum apolipoprotein A-I (ApoA-I) levels in Chinese adults with spinal cord injury (SCI) and compare the differences among different subgroups for exploring the possible mechanism and clinical significance of ApoA-I differences. Method: A total of 2240 SCI patients who admitted into China Rehabilitation Research Center (CRRC) for rehabilitation therapy from Jan 2004—Dec 2010 were investigated.ApoA-I was measured by standard laboratory method. Result: Female SCI patients showed higher ApoA-I levels than male SCI patients, and paraplegic patients showed higher ApoA-I levels than tetraplegic patients. Male SCI patients' ApoA-I level was correlated positively to age and duration of SCI, but female patients did not. Conclusion: ApoA-I levels were significantly different between paraplegias and tetraplegias, so were between male and female patients. The differences maybe resulted from estrogen protection effect and differences of exercise capacities.
Keywords:apolipoprotein A-I  spinal cord injury  gender  exercise
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