何 冰,卢国华,杨增云,范静波,张媛媛,张兰娥,张莹莹.认知干预训练对轻度认知功能障碍患者认知功能和事件相关电位P300的影响[J].中国康复医学杂志,2013,28(11):1006~1009 |
认知干预训练对轻度认知功能障碍患者认知功能和事件相关电位P300的影响 点此下载全文 |
何 冰 卢国华 杨增云 范静波 张媛媛 张兰娥 张莹莹 |
山东省潍坊医学院护理学院,261053 |
基金项目:山东省自然科学基金项目(ZR2010HM042, ZR2011HM002) |
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摘要
目的:探讨认知干预训练对轻度认知功能障碍(MCI)患者认知功能的影响和听觉事件相关电位P300改变的特点。
方法:2010年12月至2012年12月从潍坊社区筛选MCI患者50例作为研究对象,随机分为两组,应用简易精神状态量表(MMSE)和事件相关电位P300评估两组受试者训练前后的认知干预效果。
结果:干预前两组患者P300潜伏期、波幅及MMSE得分无显著性差异(P>0.05),经过6个月的干预后,干预组P300潜伏期(350.90±15.85)比干预前缩短(P<0.05),与对照组(370.04±21.25)相比明显缩短(P<0.01);波幅(12.01±1.95)与对照组相比增高(P<0.05);MMSE得分(26.19±1.21)比干预前增加(P<0.05),与对照组(24.52±1.34)相比明显增加(P<0.01)。对照组P300潜伏期、波幅及MMSE得分与6个月前相比变化均不明显(P>0.05)。
结论:认知训练可以有效延缓认知功能的下降,明显改善MCI患者的认知功能状况。听觉事件相关电位P300测定可以作为对MCI患者干预前后认知功能定量评价的工具。 |
关键词:认知干预训练 听觉事件相关电位P300 简易精神状态量表 轻度认知功能障碍 |
The effect of cognitive intervention training on cognitive ability and auditory event related potential P300 in patients with mild cognitive impairment Download Fulltext |
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Shandong Weifang Medical University, School of Nursing, 261053 |
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Abstract
Objective:To discuss the affects of cognitive intervention training on cognitive ability and auditory event related potential P300 in patients with mild cognitive impairment(MCI).
Method:Patients with MCI were randomly assigned either to cognitive intervention groups, receiving a 6-month cognitive intervention, or control group, receiving no intervention. Mini mental state examination (MMSE) and auditory event related potentials(ERPs) P300 test were administered at baseline and after six-month intervention to evaluate the intervention effect.
Result:After six months, the P300 latency periods of intervention group(350.90±15.85) were shorter than before (P<0.05), and significantly shortened compared with control group (370.04±21.25,P<0.01); The amplitude (12.01±1.95) increased comparing with control group(P<0.05);the scores of MMSE(26.19±1.21)were higher than before(P<0.05)and significantly higher compared with control group(24.52±1.34)(P<0.01). The changes of P300 latency, amplitude and MMSE scores were not significant in control group (P>0.05).
Conclusion:Cognitive training can effectively prolong the decline of cognitive function improve the cognitive function significantly in MCI patients. Auditory ERPs P300 test can be used as a quantitative evaluation tool of cognitive function before and after the intervention for MCI patients. |
Keywords:cognitive intervention training auditory event related potential P300 mini metal state examination mild cognitive impairment |
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