不同电压的骶神经刺激对脊髓损伤大鼠肠道功能的影响

关键词：骶神经电刺激  电压  刺激参数  脊髓损伤  肠道功能障碍  大鼠

Keywords:sacral nerve stimulation  voltage  stimulation parameter  spinal cord injury  bowel dysfunction  rat

摘要：

      摘要 目的：研究不同电压的骶神经刺激对脊髓损伤大鼠肠道的影响，寻求最佳的刺激参数。 方法：应用RM6240c将不同刺激电压1V、2V、4V、8V分别作用于脊髓损伤大鼠的骶神经根,刺激7d后，通过测定各组大鼠的肠道生物电、肠道通透性、肠道动力以及肠道的形态学改变来比较各组的肠道功能恢复差异。 结果：不同刺激组肠道生物电峰值和肠道动力均高于对照组，肠道通透性以及肠道的形态学较对照组都有不同程度的改善，差异均有显著性意义（P<0.05）。 结论：不同电压的骶神经刺激均能够改善脊髓损伤大鼠肠道功能障碍，其中刺激电压4V对脊髓损伤后大鼠肠道功能的改善最明显。

Abstract:

      Abstract Objective：To investigate the effects of different voltages of sacral nerves stimulating on bowel after spinal cord injury in rats to obtain the best stimulating parameters. Method：Rats with spinal cord injury were stimulated at different voltages (1V, 2V, 4V, 8V). Changes of colonic motility, colon myoelectric activity waveforms peak value, colon permeability and gut microstructure of the rats were used to assess the bowel function. Result：The changes of colonic motility, colon myoelectric activity waveforms peak value, colon permeability and gut microstructure in stimulation group were better than that in control group at day 7(P<0.05). Conclusion：The different voltages of sacral nerves stimulating could improve bowel function in rats with spinal cord injury. The best stimulating parameter was intensity of 4V.