吴明方,陆阿明.有氧运动及其联合饮食干预影响非酒精性脂肪肝患者血浆SREBP-1c、RBP4水平的研究[J].中国康复医学杂志,2015,(2):132~137 |
有氧运动及其联合饮食干预影响非酒精性脂肪肝患者血浆SREBP-1c、RBP4水平的研究 点此下载全文 |
吴明方 陆阿明 |
苏州大学体育学院,苏州,215021 |
基金项目:国家社会科学基金项目(11BPY045) |
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摘要
目的:探讨有氧运动、饮食控制对非酒精性脂肪性肝病(NAFLD)患者血清SREBP-1c、RBP4水平的影响。
方法:将NAFLD患者共53例随机分为对照组(C)、运动组(E)、饮食控制组(D)和运动+饮食控制组(ED);另有12例健康自愿者组成健康对照组(N)。E组运动处方干预,D组饮食干预,ED组运动联合饮食干预。实验前后分别检测身体形态(BMI;WHR)和血液生化指标(SREBP-1c;RBP4;TNF-a等)。
结果:①WHR指数实验后E组、DE组较实验前显著下降(P<0.05);实验后DE组较C、E组显著下降(P<0.05)。②血浆TG及LDL/HDL实验后E组、DE组较实验前显著下降(P<0.05);实验后DE组血浆TG、E组和DE组LDL/HDL较C组显著降低(P<0.05)。③血浆FINS水平及HOMA-IR实验后E、DE组较实验前显著下降(P<0.05);实验后HOMA-IR指数E组和DE组较C组显著下降(P<0.05)。④E组RBP4、D组SREBP-1c和DE组TNF-α、RBP4、SREBP-1c血浆水平实验后较实验前显著下降(P<0.05);实验后E组SREBP-1c水平和DE组血浆RBP4、SREBP-1c水平较C组显著降低(P<0.05)。
结论:①16周有氧运动、饮食控制以及有氧运动联合饮食控制,NAFLD患者血浆SREBP-1c、RBP4、TNF-α水平分别呈不同程度降低,IR缓解,脂质代谢紊乱改善,有利于NAFLD转归。②有氧运动联合饮食控制对NAFLD的干预效果更佳。 |
关键词:非酒精性脂肪肝 有氧运动 饮食控制 固醇调节元件结合蛋白-1c 视黄醇结合蛋白4 肿瘤坏死因子α |
Effects of aerobic exercise combined with controlled diet on the serum level of SREBP-1c and RBP4 in patients with non-alcoholic fatty liver disease Download Fulltext |
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PE Institute of Suzhou University, Suzhou, 215021 |
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Abstract: |
Abstract
Objective: To study the effects of aerobic exercise combined with controlled diet on the serum level of SREBP-1c and RBP4 in non-alcoholic fatty liver disease (NAFLD) patients.
Method: Fifty-three NAFLD patients were randomly divided into 4 groups: exercise combined with diet control (DE), exercise only (E), diet control only (D) and the control group (C); with 12 healthy subjects to make a healthy control group (NC). The body mass index(BMI), waist/hip ratio (WHR) and the blood indexes SREBP-1c, RBP4 and TNF-α were examined before and after the trial. The data statistics were undergoing afterwards.
Result: ① The WHR decreased significantly after the trial in groups E and DE (P<0.05). The WHR in group DE was lower markedly than that in C and E (P<0.05). ② The serum TG and LDL/HDL in groups E and DE decreased significantly (P<0.05). The serum TG in group DE was significantly lower than that of group C. The serum LDL/HDL in groups E and DE (P<0.05) was lower than that of group C. ③ The serum FINS and HOMA-IR in groups E and DE decreased significantly (P<0.05). The serum HOMA-IR in groups DE and E were significant lower than that of group C (P<0.05). ④ The serum RBP4 in group E, SREBP-1c in group D, and TNF-α, RBP4 and SREBP-1c in group DE decreased significantly (P<0.05). The serum SREBP-1c in group E was significantly lower than that of group C. The serum RBP4 and SREBP-1c in group DE (P<0.05) were also lower than that of group C.
Conclusion: ① The 16-week of aerobic exercise or diet control or their combination will differently decrease the serum level of SREBP-1c, RBP4, TNF-α in NAFLD patients, resulting in the relief of IR and the lipid metabolism disorder. Therefore, this will improve the prognosis and outcome of the disease. ② The combination of aerobic exercise and diet control has the most effective effect in NAFLD. |
Keywords:non-alcoholic fatty liver disease aerobic exercise diet control sterol regulatory element-binding protein-1c retinol binding protein 4 tumor necrosis factor-α |
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