有氧训练对阿尔茨海默病的干预作用研究

关键词：阿尔茨海默病  有氧训练  简明精神状态量表  日常生活活动能力  生活质量

Keywords:Alzheimer's disease  aerobic training  mini-mental state examination  ability of activities of daily living  quality of life

摘要：

      摘要 目的：探讨有氧训练对阿尔茨海默病（AD）患者的治疗作用。 方法：将60例AD患者分为有氧训练组（30例）和对照组（30例），所有入组患者均按AD常规治疗，试验组接受强度分别为50%—70%最大强度的16周有氧训练，每次持续60—90min，每周3次。分别在治疗前、8周和16周后利用简明精神状态量表（MMSE）、日常生活能力量表（ADCS-ADL）和生活质量量表（QOL-AD）对两组患者进行认知功能、ADL能力、生活质量评价，并在治疗前和治疗16周后利用临床医生面谈印象变化量表（CIBIC plus）对AD患者临床总体印象变化进行评价。 结果：试验组有3例患者未完成规定的有氧训练；有氧训练对患者的血尿常规、心电图及血生化指标无显著影响（P＞0.05）；与对照组相比，有氧训练组MMSE评分、ADCS-ADL评分和QOL评分在8周和16周均较基线明显改善（P＜0.05）；有氧训练组在第16周时ADCS-ADL评分较第8周时明显降低（P＜0.05）；16周时，试验组患者总体临床印象变化CIBIC plus改善率是对照组患者的3.5倍。 结论：有氧训练疗法可显著改善AD患者认知功能、ADL能力、生活质量和临床总体印象，有氧训练可以作为AD辅助治疗的有效手段。

Abstract:

      Abstract Objective: To evaluate the clinical efficacy of aerobic training on patients with Alzheimer's disease. Method: Sixty patients with mild to moderate Alzheimer's disease all received AD conventional treatment and were randomly allocated into 2 groups: acrobic training group and control group. Aerobic training group were treated with aerobic training at 50%—70% of maximal intensity for 16 weeks. The efficacy of aerobic training was evaluated by mini-mental status examination(MMSE), Alzheimer's disease cooperative-study-activities of daily living(ADCS-ADL) and QOL-AD. At baseline, the end of 8 weeks and the end of 16 weeks. Clinioian interview baced impression of change plus(CIBIC plus) was also evaluated at baseline and the end of 16 weeks. Result: Three participants dropped out from the aerobic training group for the failure of fulfilling the training plan. Compared with control group, patients of aerobic training group got statistically significant improvement in MMSE, QOL-AD and ADCS-ADL (P＜0.05). In the aerobic training group, the scores of ADCS-ADL at the end of 16 weeks was significantly lower than that at the end of 8 weeks (P＜0.05). At the end of 16 weeks, the percentage of significant improved CIBIC plus value in aerobic training group was 3.5 times as many as that in control group. Conclusion: Aerobic training could improve the cognitive function, ability of activity of daily living, quality of life and clinical symptoms of AD patients, with acceptable safety and tolerance.