利用事件相关电位探索三种听觉Oddball范式脑加工机制的研究

关键词：事件相关电位  P300  失匹配负波  慢性意识障碍  植物状态  无反应觉醒综合征  最小意识状态

Keywords:event-related potentials  P300  mismatch negativity  vegetative state  unresponsive wakefulness syndrome  minimally conscious state

摘要：

      摘要 目的：开发一组新的听觉Oddball范式，通过事件相关电位观察其在健康受试者中的脑加工反应。 方法：社会招募健康志愿者15名（男8名，女7名，平均年龄40±9岁），分别进行纯音-正名（TS），其他名字-正名（OS）和反名-正名（RS）三组难度依次增大的听觉Oddball范式的事件相关电位检查，分析比较各组MMN和P300潜伏期和波幅的差异。 结果：三组实验范式在所有健康志愿者中均诱发得到失匹配负波(mismatch negativity, MMN)和P300，TS组MMN和P300的潜伏期最短，OS组次之，RS组最长（P<0.05），但OS组和RS组统计学分析无显著性差异（P>0.05）；MMN的波幅TS组最大，OS组次之，RS组最小（P<0.05），但OS组和RS组统计学分析无显著性差异（P>0.05）；各组之间P300波幅比较未发现显著性差异（P>0.05）。 结论：三组听觉Oddball实验范式有一定的区分难度，有望进一步应用于植物状态/无反应觉醒综合征患者和最小意识状态患者的鉴别诊断和预后预测。

Abstract:

      Abstract Objective: To observe brain processing mechanism of the three auditory Oddball paradigms, which were developed in this study in the healthy volunteers. Method: Fifteen healthy volunteers(eight men and seven women, between 28 to 58 years, mean 40±9 years）were recruited from community. Three auditory Oddball paradigms were used in the active event-related potentials (ERP) study, including TS paradigm (tone and subject’s own name), OS paradigm (other first name and subject’s own name) and RS paradigm (reversed subject’s own name and subject’s own name). The amplitude and latency of P300 and mismatch negativity(MMN) among three paradigms were analyzed. Result: Among all volunteers, MMN and P300 were observed in all three paradigms. As for the latency of P300 and MMN, TS paradigm was the shortest, OS paradigm came second, and RS paradigm was the longest (P<0.05). However, OS paradigm and RS paradigm had no significant differences (P>0.05). As for the amplitude of MMN, TS paradigm was the highest, OS paradigm came second, and RS paradigm was the lowest (P<0.05). However, there was no significant difference between OS paradigm and RS paradigm(P>0.05). The amplitude of P300 had no significant differences among the three paradigms (P>0.05). Conclusion: Three auditory Oddball paradigms had different difficulty degrees and was expected to be used in the discrimination and prognosis of vegetative state/unresponsive wakefulness syndrome (VS/UWS) patient and minimally conscious state patient in future.