肌少症不同分级与10年动脉粥样硬化性心血管病发病风险的相关性研究

关键词：肌少症  10年动脉粥样硬化性心血管疾病  发病风险  肌肉质量

Keywords:sarcopenia  10-year atherosclerotic cardiovascular disease  morbidity risk  muscle mass

摘要：

      摘要 目的：探究肌少症不同分级与10年动脉粥样硬化性心血管疾病（atherosclerotic cardiovascular disease，ASCVD）发病风险的相关性，为肌少症不同时期干预降低ASCVD发生风险提供依据。 方法：研究对象取自2021年1月—2022年6月在北京市中关村医院完成“65岁及以上老年人体检项目”的1072例老年人，其中男性408例，女性664人例。对受试者进行信息采集、体格检查、生化检测、身体成分测试和功能体适能测试。根据握力、5次起坐试验时间和四肢骨骼肌质量指数（appendicular skeletal muscle mass index，ASMI）综合判定肌少症分级，将研究对象分为肌少症可能组、肌少症前期组、肌少症组和对照组。比较四组受试者的临床特点，并采用二元logistic回归分析肌少症不同分级与10年ASCVD发病风险之间的关系。 结果：本研究肌少症患病率为10.6%，肌少症可能和肌少症前期检出率分别为16.1%和15.1%。男性肌少症前期[OR：95%Cl=3.63（1.03—12.78），P=0.04]和肌少症组[OR：95%Cl=8.90（1.15—68.86），P=0.04]与ASCVD 10年发病高风险相关，女性肌少症组[OR：95%Cl=5.05（1.49—17.13），P=0.009]与ASCVD 10年发病高风险明显相关。 结论：男、女肌少症患者和男性肌肉质量下降人群的10年ASCVD发病风险较高，且肌少症严重程度和ASCVD发病风险正相关，这对于早期预防心血管疾病具有重要意义。

Abstract:

      Abstract Objective：To analyze the correlation between different grades of sarcopenia and 10-year atherosclerotic cardiovascular disease risk，and provide the scientific evidence for prevention of sarcopenia and cardiovascular disease. Method：The study included 1,072 elderly individuals who completed physical examination program for seniors 65 years and older at Beijing Zhongguancun Hospital from January 2021 to June 2022, consisting of 408 men and 664 women. The investigation was performed with the questionnaires， physical examination， biochemical， body composition and physical performance test. According to handgrip strength， 5-time chair stand test and ASMI， the subjects were divided into control， possible sarcopenia， pre-sarcopenia and sarcopenia group. Binary logistic regression method was used to analyze the data. Result：The prevalence of disease for sarcopenia was 10.6%， with the detection rates of possible sarcopenia and pre-sarcopenia being 16.1% and 15.1%, respectively. In male, pre-sarcopenia [OR： 95%Cl=3.63（1.03—12.78），P=0.04] and sarcopenia [OR：95%Cl=8.90（1.15—68.86），P=0.04] were correlated with a high 10-year risk of atherosclerotic cardiovascular disease. In female, sarcopenia [OR： 95%Cl=5.05（1.49—17.13），P=0.009] was significantly correlated with a high 10-year risk of atherosclerotic cardiovascular disease. Conclusion：Both male and female elderly sarcopenia patients, as well as males with reduced muscle mass, have a higher 10-year risk of developing ASCVD. The severity of sarcopenia is positively correlated with the risk of ASCVD, underscoring the importance of early prevention of cardiovascular disease.Abstract Objective：To analyze the correlation between different grades of sarcopenia and 10-year atherosclerotic cardiovascular disease risk，and provide the scientific evidence for prevention of sarcopenia and cardiovascular disease. Method：The study included 1,072 elderly individuals who completed physical examination program for seniors 65 years and older at Beijing Zhongguancun Hospital from January 2021 to June 2022, consisting of 408 men and 664 women. The investigation was performed with the questionnaires， physical examination， biochemical， body composition and physical performance test. According to handgrip strength， 5-time chair stand test and ASMI， the subjects were divided into control， possible sarcopenia， pre-sarcopenia and sarcopenia group. Binary logistic regression method was used to analyze the data. Result：The prevalence of disease for sarcopenia was 10.6%， with the detection rates of possible sarcopenia and pre-sarcopenia being 16.1% and 15.1%, respectively. In male, pre-sarcopenia [OR： 95%Cl=3.63（1.03—12.78），P=0.04] and sarcopenia [OR：95%Cl=8.90（1.15—68.86），P=0.04] were correlated with a high 10-year risk of atherosclerotic cardiovascular disease. In female, sarcopenia [OR： 95%Cl=5.05（1.49—17.13），P=0.009] was significantly correlated with a high 10-year risk of atherosclerotic cardiovascular disease. Conclusion：Both male and female elderly sarcopenia patients, as well as males with reduced muscle mass, have a higher 10-year risk of developing ASCVD. The severity of sarcopenia is positively correlated with the risk of ASCVD, underscoring the importance of early prevention of cardiovascular disease.