单纯性肥胖者胃容受性及胃内压的检测

关键词：单纯性肥胖暴食症  容受性  胃内压  电子恒压器

Keywords:simple obesity with sufeit  gastric accommodation  introgastric pressure  electronic barostat

摘要：

      目的：探讨单纯性肥胖伴暴食症者胃容受性及胃内压与肥胖之间的关系。方法：40例单纯性肥胖暴食症者为试验组，35例健康正常体重者为对照组。试验第一天对受试者进行水负荷试验。第二天采用电子恒压器对受试者进行胃底机械性扩张，检测胃容受性、胃内压及顺应性。结果：①单纯性肥胖伴暴食症组最大负荷饮水量显著大于正常体重对照组（P<0.001）。②单纯性肥胖伴暴食症组初始容积和最大耐受容积较对照组均显著增大（P<0.001）。③单纯性肥胖伴暴食症组最小扩张压、初始胃内压和最大耐受胃内压与对照组比较差异均无显著性意义（P>0.05）。④单纯性肥胖伴暴食症组最小顺应性与对照组比较差异无显著性意义（P>0.05），而初始顺应性和最大耐受顺应性比对照组显著增大（P<0.001）。结论：单纯性肥胖伴暴食症组胃容积、胃容受性、顺应性较正常体重对照组明显增大，而胃内压无差异，胃容积增加、顺应性增大、容受性增强、饱感延迟发生可能是肥胖发生的重要原因。

Abstract:

      Objective：To evaluate the relation of accommodation, intragastric pressure and obesity in simple obesity with surfeit. Method： Fourty simple obesity with surfeit subjects and 35 non-obese healthy subjects were enrolled in the study. On the first day, the water load test was performed. On the second day, accommodation, intragastric pressure and gastric compliance using an electronic barostat were measured by mechanical distension. Result：①The water consumption in the obese group was significantly increased in comparison with that in control group(P<0.001).②The initial volume(IV) and maximal tolerance volume(MV) in the obese group were significantly larger than those in control group（P<0.001）.③The minimal distension pressure(MDP), initial intragastric pressure(IP) and maximal tolerance pressure(MP) in the obese group compared with those in control group were no significant difference respectively （P>0.05）.④The minimal distention compliance(MDC) in the obese group was not significantly different from the control group（P>0.05）, but initial gastric compliance(IC) and maximal tolerance compliance(MC) were remarkably higher than those in control group respectively（P<0.001）. Conclusion：Gastric capacity, gastric accommodation and compliance increased in simple obesity with surfeit group and intragastric pressures were not different from control group. The simple obesity with surfeit may attribute to enlarged gastric capacity, gastric accommodation and compliance which cause an increase in food intake and delayed satiety. These findings may be one of main mechanisms of obesity in glattons.