基于功能性近红外光谱的不同模式外周刺激对成人皮质功能活动的影响

关键词：功能性近红外光谱  脑激活  神经肌肉电刺激  外周磁刺激

Keywords:functional near infrared spectroscopy  cortical activation  neuromuscular electrical stimulation  peripheral magnetic stimulation

摘要：

      摘要 目的：研究采用功能性近红外光谱（fNIRS）探究神经肌肉电刺激（NMES）和外周磁刺激（PMS）对健康成年受试者大脑皮质激活模式作用的差异 方法：15例健康成年受试者按照随机顺序接受NMES和PMS干预，两者均应用于受试者优势手前臂处诱发腕伸展运动，我们测量了NMES和PMS刺激过程中7个感兴趣区域（ROIs）的氧合血红蛋白（HbO2）和脱氧血红蛋白（HbR），根据HbO2及HbR的浓度变化观察两种外周刺激对脑区激活的作用差异。 结果：NMES刺激期间，除双侧S1区域外，12个脑区内38个通道HbO2值变化较休息期间明显降低（P<0.05）；PMS刺激时6个通道的HbO2值显著变化，左侧M1区刺激肌肉支配区（通道35）HbO2值高于其他ROI（P<0.05）；PMS刺激时左侧M1区域手运动区（通道23、35）HbO2激活显著强于NMES刺激时（P<0.05）。根据HbR值，与休息期相比，两种不同刺激模式所激活的通道数相同。 结论：基于HbO2值变化，PMS和NMES均可增加刺激肌肉支配皮质区域功能活动，PMS可区域性激活皮质功能活动。

Abstract:

      Abstract Objective：To investigate the change of cortical activation pattern during wrist extension in health subjects induced by neuromuscular electrical stimulation （NMES） and peripheral magnetic stimulation （PMS）， using functional near infrared spectroscopy （fNIRS）. Method：Fifteen health adults received 2 randomly ordered interventions（NMES and PMS），which were applied to the dominant wrist extensor muscle to induce wrist extention. Qxy-hemoglobin （HbO2） and deoxygenated hemoglobin （HbR） were measured in seven regions of interest （ROI） during NMES and PMS stimulation. The difference between these two non-invasive peripheral stimulation on the cortical activation was recorded in the changes of HbO2 and HbR concentrations. Result：During NMES motor phase, HbO2 values of 38 channels in ROI except bilateral S1 region showed a significant decreased compared with the rest period（P<0.05）. The HbO2 values of six channels were significantly changed in PMS motor phase， and the activated channels were concentrated on M1 region. The HbO2 values of the left M1 region of hand movement area (channel 35) were higher than other ROI (P<0.05）. The activation of HbO2 in the left M1 hand movement area (channels 23 and 35) was significantly stronger in PMS motor phase than in NMES motor phase (P<0.05）. Based on HbR values, both NMES and PMS activated the same number of channels compared to the rest period. Conclusion：The results showed that NMES induced wrist extension could lead to decreased cortical activation in multiple brain regions， and PMS induced more concentrated and effective cortical activation than NMES. PMS likely via massive inflows of ‘pure’ proprioceptive information. Both PMS and NMES can increase the stimulation of functional activity in parts of muscle-innervated cortex based on changes in HbO2 values, with PMS stimulating cortical functional activity regionally.