Theta爆发式经颅磁刺激对脑卒中后运动性失语症患者视图命名的疗效研究

关键词：脑卒中  失语症  运动性失语  经颅磁刺激  θ节律刺激  视图命名

Keywords:stroke  aphasia  motor aphasia  transcranial magnetic stimulation  Theta burst stimulation  picture naming

摘要：

      摘要 目的：初步探讨iTBS刺激大脑左半球Broca区对脑卒中后左侧额叶损伤的运动性失语症患者视图命名功能的影响。 方法：连续纳入2021年9月—2023年5月于我科病房住院和门诊治疗的失语症患者35例，随机将入组患者分为对照组17例、试验组18例；两组患者均接受相同训练强度和内容的言语语言治疗，每次训练30min，2次/天，训练10天；同时试验组采用iTBS刺激大脑左半球Broca区，1次/天，治疗10天。治疗前及治疗后进行视图命名（训练项和非训练项）的评估。 结果：两组患者治疗前训练项和非训练项视图命名成绩无显著性差异（P＞0.05）；治疗2周后，两组患者训练项命名成绩均较治疗前有明显提高（P＜0.05）；其中试验组较对照组有显著提高（P＜0.05），治疗后两组命名成绩分别为（16.88±4.211）、（19.28±3.028）。非训练项命名成绩较治疗前有显著提高（P＜0.05）；且较对照组有显著提高（P＜0.05）；治疗后两组非训练项命名成绩分别为（13.18±3.187）、（19.11±3.563）。 结论：iTBS结合言语语言治疗对左侧额叶损伤的运动性失语症患者视图命名效果有一定治疗效果，且可显著提高言语语言治疗的泛化效果。

Abstract:

      Abstract Objective： To investigate the effect of iTBS stimulation of left hemisphere Broca region on view naming function in patients with motor aphasia after stroke. Method： A total of 35 patients with aphasia who were treated in the department of rehabilitation medicine， Xuanwu hospital， capital medical university from September 2021 to May 2023 were retrospectively included. The enrolled patients were randomly divided into control group （n=17） and experimental group （n=18）. Both groups received speech and language therapy with the same training duration and content， which consisted of pictures of training items. Meanwhile， iTBS was used to stimulate the left hemisphere Broca region in the experimental group. Picture naming （training items and non-training items） was evaluated before treatment and 2 weeks after treatment. Result： There was no statistical difference between the two groups before treatment （P>0.05） in the naming results of training items and non-training items. After 2 weeks of treatment， the results of naming training items in both groups were significantly improved compared with before treatment （P<0.05）. The experimental group was significantly higher than the control group（P<0.05）， with the naming scores of the two groups after treatment were （16.88±4.211） and （19.28±3.028）， respectively. The results of naming non-training items were significantly higher than those before treatment（P<0.05）and significantly higher than those in control group（P<0.05）. After treatment，the results of non-training items were （13.18±3.187） and （19.11±3.563） respectively. Conclusion： iTBS combined with speech language therapy has a certain therapeutic effect on the picture naming ability of motor aphasia patients with left frontal lobe injury， and can significantly improve the generalization effect of speech language therapy.