| 徐丽丽,白玉龙,胡永善,吴 毅,崔 晓,朱大年.运动训练改善脑缺血大鼠梗死体积与神经行为能力的实验研究[J].中国康复医学杂志,2008,23(2):100~102 |
| 运动训练改善脑缺血大鼠梗死体积与神经行为能力的实验研究 点此下载全文 |
| 徐丽丽 白玉龙 胡永善 吴 毅 崔 晓 朱大年 |
| 复旦大学附属华山医院康复医学科，复旦大学上海医学院康复与运动医学系,上海市乌鲁木齐中路12号，200040 |
| 基金项目：复旦大学基础和临床交叉基金（校200681）；上海市长宁区卫生局科研基金资助项目（2004104001） |
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| 摘要： |
| 目的：观察运动训练能否促进大鼠局部脑缺血再灌注后的神经功能恢复，并且观察早期运动训练对脑缺血再灌注后梗死体积的影响，从而探讨其促进功能恢复的机制。方法：成年雄性SD大鼠24只，随机分成运动训练组、对照组和假手术组，每组8只。大脑中动脉闭塞（MCAO）法造模24h后，运动训练组给予跑台训练，每天30min，连续训练2周，对照组及假手术组给予相同的抓取和固定。采用神经行为学评分评价造模情况及神经功能的恢复情况；甲苯胺蓝染色观察大鼠局部脑缺血再灌注后梗死体积的大小。结果：2周后，运动训练组的神经行为学评分明显高于对照组（P<0.05），并低于假手术组（P<0.05）；运动训练组的脑梗死体积明显小于对照组（P<0.05）。结论：脑缺血再灌注后早期运动训练能够减小脑梗死体积，促进脑缺血大鼠神经功能的恢复。 |
| 关键词：脑缺血再灌注 运动训练 梗死体积 |
| The effect of physical training on the infarct volume and neurological behavior after focal cerebral ischemia and reperfusion in rats Download Fulltext |
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| Dept. of Rehabilitation，Huashan Hospital，Fudan University，Shanghai，200040 |
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| Abstract: |
| Objective:To investigate whether physical training can improve neurological function and reduce the infarct volume after focal cerebral ischemia. Method:Twenty-four male adult Sprague-Dawley rats(2—3month old) were subjected to 60 mins right middle cerebral artery occlusion(MCAO). All rats were randomly assigned to one of the three groups: physical training group, control group and sham operation group. Physical training group underwent 30 mins treadmill training per day for 2 weeks 24h after MCAO procedure. Result:After two weeks, the neurological score in physical training group was higher than those underwent spontaneous recovery（P<0.05）.The infarct volume in physical training group was smaller than the controls（P<0.05）. Conclusion: Physical training can improve neurological function and reduce the infarct volume after focal cerebral ischemia and reperfusion. |
| Keywords:cerebral ischemia and reperfusion physical training infarct volume |
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