不同运动量对小鼠微循环及耐缺氧能力的影响

关键词：运动  微循环  亚硝酸钠  急性缺氧

Keywords:exercise  microcirculation  sodium nitrite  acute anoxia

摘要：

      目的：研究不同运动量对小鼠微循环及耐缺氧能力的影响。方法：昆明种小鼠采用转笼法运动4周后，采用BI-2000图像分析系统测定小鼠耳廓微血管管径及血流速度, 采用小鼠急性脑缺血性缺氧实验、亚硝酸钠模型常压耐缺氧实验，观察并记录小鼠断头后张口呼吸时间及耐缺氧存活时间。结果：与空白对照组比较，高运动组小鼠耳廓微动脉、微静脉流速、微动脉管径均显著增加（P<0.05）；中运动组小鼠耳廓微动脉管径均显著增加（P<0.01）；低运动组小鼠耳廓微动流脉速径及微动脉管均显著增加（P<0.05）。高、中、低运动组小鼠断头后张口呼吸时间均显著延长（P<0.05）；高、低运动组和尼莫地平组小鼠亚硝酸钠模型常压耐缺氧时间均显著缩短（P<0.05）。结论：运动训练具有改善小鼠微循环，增强小鼠耐缺氧能力的作用且与运动量有一定的相关性。

Abstract:

      Objective:To study the effects of various exercises quantity on microcirculation and anti-hypoxia ability in mice. Method: The mice of exercises group were administered to exercise in running wheels, The BI-2000 image system was used to evaluate the diameter and velocity of microcirculation in mice′s auricle after 4 weeks of exercises. Acute anoxia in mice were produced by sodium nitrite hypoxia under normal pressure and decapitation. In these two models the survival time and persistent time of gasping were observed. Result: Comparing with control group, in exercises groups the velocity of microcirculation in mice auricle significantly speeded up(P<0.05); the diameters of microartery dilated(P<0.05); after decapitation the gasping time prolonged significantly(P<0.05). In sodium nitrite hypoxia model the survival time in exercises groups and nimodipine group shortened significantly(P<0.05). Conclusion:Exercises can improve the microcirculation and enhance the capacity of anti-anoxia in mice and the effect is related to exercises quantity.