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吴亚文,江钟立,李红卫,陈 玲.运动训练对糖尿病大鼠胰岛形态和β细胞功能的影响*[J].中国康复医学杂志,2009,24(6):518~522
运动训练对糖尿病大鼠胰岛形态和β细胞功能的影响*    点此下载全文
吴亚文  江钟立  李红卫  陈 玲
南京医科大学第一附属医院康复医学科,210029
基金项目:江苏省卫生厅“科教兴卫工程”开放课题
DOI:
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摘要:
      目的:探讨运动训练对糖尿病大鼠血清和胰腺胰岛素水平及胰岛形态学的影响。方法:链脲霉素诱导的糖尿病大鼠14只,随机平均分配到对照组和运动组,实验结束时存活的糖尿病大鼠11只,其中糖尿病对照组5只,糖尿病运动组6只;正常血糖大鼠12只,随机分为正常对照组(n=6)和正常运动组(n=6)。运动程序为每天游泳1h,持续8周。实验结束后取血和胰腺标本,分别测定血糖、血清胰岛素和组织胰岛素含量;运用图像分析软件Image-Pro Plus 6.0进行胰腺病理形态学分析。结果:糖尿病运动组血糖有明显下降趋势(P=0.0
关键词:运动训练  糖尿病  胰岛素  胰岛形态学
The effects of exercises training on pancreatic islets morphology and β-cell function in diabetic rats    Download Fulltext
Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029
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Abstract:
      Objective: To explore the effects of exercises on pancreatic islet morphology and β-cell function in streptozotocin-induced diabetic rats. Method: Fourteen diabetic rats induced by streptozotocin (STZ, 55mg/kg) were randomly divided into exercises group and control group. Eleven diabetic rats survived at the end of experiment, which were distributed respectively in diabetic exercises group(n=6) and diabetic control group(n=5). Twelve SD rats with euglycemia were randomly divided to normal control group(n=6) and normal exercises group(n=6). The exercises rats were forced to swim 60min/d for 8 weeks. At the end of experiment, fasting blood glucose and insulin in pancreatic tissues were measured by radioimmunoassay(RIA). The morphology of pancreatic islet was evaluated by means of Image-Pro Plus6.0. Result: After an 8-week study, blood glucose levels trended to decrease in diabetic exercises group (P=0.053). The levels of insulin in serum and pancreatic tissues in diabetic exercises group were significantly higher than that in diabetic control group(P<0.05) and lower than normal exercises group(P<0.05). The level of insulin in pancreatic tissue were significantly higher in normal exercises group than that in normal control group(P<0.05). The morphology of pancreatic islets showed that the size and the number of islets significantly increased(P<0.05) and shape factor(SF) decreased(P<0.05)in diabetic exercises group compared with diabetic control group. Conclusion: Regular exercises training can improve level of insulin in serum and pancreatic tissue and recover pancreatic islets morphology. It suggests that exercises training may partly enhance β-cell function.
Keywords:exercises training  diabetes  insulin  pancreatic islet morphology
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