针刺曲池、外关穴时间依赖性调节运动皮质兴奋性的研究

关键词：针刺  穴位  经颅磁刺激  皮质兴奋性  时间依赖性

Keywords:acupuncture  acupoints  excitability  motor cortex  time-dependent

摘要：

      摘要 目的：探讨单侧针刺曲池、外关穴针刺前、留针时及拔针后不同时间点对健康受试者双侧运动皮质兴奋性的影响。 方法：将18例健康受试者按照随机数字表法分成针刺组和伪针刺组，每组9例。分别给予针刺和伪针刺干预。于针刺前10min、进针后30min及拔针后20min分别使用经颅磁刺激运动诱发电位检测皮质兴奋性（每30s 1次）。 结果：①与针刺前比较，针刺组留针时针刺对侧M1区MEP波幅比降低，留针时针刺同侧及拔针后针刺双侧M1区MEP波幅比均升高，且均有显著性差异（P<0.01）；②与针刺前比较，伪针刺组留针时及拔针后针刺双侧M1区MEP波幅比均无显著性差异（P>0.05）。 结论：单侧针刺曲池、外关穴可以时间依赖性的调节健康受试者双侧M1区皮质兴奋性。

Abstract:

      Abstract Objective:To investigate the effects of acupuncture at Quchi(LI11) and Waiguan(SJ5) acupoints on the bilateralized motor cortex(M1) excitability in healthy volunteers. Method:Eighteen subjects were randomly divided into acupuncture group(n=9) or sham acupuncture group(n=9) with random number table method. Motor evoked potential(MEP) amplitudes induced by transcranial magnetic stimulation(TMS) over the bilateralized M1 in resting conditions were measured at the ‘Before’(15min before acupuncture)， ‘In’(30min with the needle in situ) and ‘After’(30min after the needle removal) phases， at 30 second intervals. Result:①Compared with before acupuncture， MEP amplitudes for the site contralateral to the acupuncture were significantly depressed when the needle in situ(P<0.01)， while MEP amplitudes for the ipsilateral site were facilitated(P<0.01)， MEP amplitudes for the bilateral were facilitated after the needle removal(P<0.01). ②Compared with before acupuncture， there was no significant change with the sham needling group. Conclusion:Acupuncture with single Quchi(LI11) and Waiguan(SJ5) acupoints could modulate the excitability of the bilateralized M1 in the time-dependent manner for the healthy volunteer.