密穗马先蒿对耐力运动小鼠红细胞参数、抗氧化和免疫功能的影响

关键词：密穗马先蒿  红细胞参数  红细胞自由基代谢  红细胞免疫黏附功能

Keywords:pedicularis densispica  morphology parameters of erythrocyte  free radical metabolism of erythrocyte  immune adhesive function of erythrocyte

摘要：

      目的：研究密穗马先蒿对耐力运动小鼠红细胞形态参数、红细胞抗氧化和免疫黏附功能的影响。方法：4周龄昆明种小鼠随机分为对照组、运动组、阳性对照组、密穗马先蒿组。运动组、阳性对照组和密穗马先蒿组进行6周的游泳训练，最后一次进行力竭游泳。力竭游泳后采用眼球取血，EDTA抗凝，测定红细胞参数、红细胞抗氧化功能及红细胞免疫黏附功能等指标。结果：实验6周后，密穗马先蒿组小鼠RBC、Hb、HCT、RBC-SOD活性和RBC-C3bR明显高于运动组（P<0.05），而MCV、RDW、RBC-ICR和RBC-MDA含量低于运动组（P<0.05）。结论:密穗马先蒿具有改善耐力运动引起的小鼠红细胞的损伤，保护小鼠红细胞的完整性，提高耐力运动小鼠红细胞的抗氧化能力和免疫功能等作用。

Abstract:

      Objective:To study the effects of pedicularis densispica on erythrocyte parameters, antioxidation and immunity capacity in endurance exercises mice. Method: The four-week old mice were divided randomly into 4 groups: control group, training group, positive control group and pedicularis densispica group. The mice in training group, positive control group and pedicularis densispica group had swimming exercises for 6 weeks, and at the last times they swam exhaustively. The morphology parameters of erythrocyte, function of erythrocyte immune and antioxidation were tested after swimming exhaustively. Result: It showed that the pedicularis densispica was effective in increasing RBC,Hb,HCT, RBC-C3bR and the activity of RBC-SOD (P<0.05), and decreasing MCV,RDW,RBC-ICR and RBC-MDA content (P<0.05), comparing to training group. Conclusion:It indicated that pedicularis densispica was effective to protect morphological integrity of erythrocyte from injury by endurance exercises，and improved antioxidation and immunity capacity of erythrocyte of mice after endarance exercises.